BDBM50534397 CHEMBL4540461

SMILES CC1(N)CCN(CC1)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl

InChI Key InChIKey=VTTSGEFPLPXNHH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50534397   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50534397(CHEMBL4540461)
Affinity DataIC50: 300nMAssay Description:Inhibition of human 6his-tagged SHP2 (2 to 593 residues) expressed in Escherichia coli BL21 Star (DE3) cells preincubated with IRS1_pY1172(dPEG8)pY12...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50534397(CHEMBL4540461)
Affinity DataIC50: 620nMAssay Description:Inhibition of SHP2 in human KYSE520 cells assessed as inhibition of ERK phosphorylation measured after 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50534397(CHEMBL4540461)
Affinity DataIC50: 300nMAssay Description:Allosteric inhibition of 6x-histidine tagged human SHP2 (Met1-L525 residues) expressed in Escherichia coli BL21 Star (DE3) using IRS1_pY1172(dPEG8)pY...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50534397(CHEMBL4540461)
Affinity DataIC50: 620nMAssay Description:Allosteric inhibition of human SHP2 in human KYSE-520 cells assessed as reduction in ERK1/2 phosphorylation by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed