BDBM50534366 CHEMBL4520767

SMILES COc1cc(ccn1)N1CCC(CC1)Nc1ncc2OCCN(CC(F)(F)F)c2n1

InChI Key InChIKey=XBXHOLRCMKVVOW-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50534366   

TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50534366(CHEMBL4520767)
Affinity DataEC50:  105nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human APP751 assessed as reduction in amyloid beta 42 production after 16 to 18 hrs by san...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed