BDBM50533863 CHEMBL4593521

SMILES COc1cccc(N2CCN(CC2)c2c(C)n(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](NCCCC(O)=O)c3ccccc3)c2=O)c1F

InChI Key InChIKey=VUOPVHLJDJPKLD-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50533863   

TargetGonadotropin-releasing hormone receptor(Human)
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50533863(CHEMBL4593521)
Affinity DataIC50: 5.40nMAssay Description:Antagonist activity against human GnRH receptor expressed in HEK293 cells co-transfected with pGL4-NFAT promoter AP1-luc assessed as inhibition of 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50533863(CHEMBL4593521)
Affinity DataIC50: 896nMAssay Description:Displacement of [125I]D-Trp6-LHRH from rat GnRH receptor expressed in HEK293 cell membranes incubated for 1 hr by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50533863(CHEMBL4593521)
Affinity DataIC50: 0.580nMAssay Description:Displacement of [125I]D-Trp6-LHRH from human GnRH receptor expressed in CHO-K1 cell membranes incubated for 1 hr by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50533863(CHEMBL4593521)
Affinity DataIC50: 32nMAssay Description:Antagonist activity against monkey GnRH receptor expressed in HEK293 cells co-transfected with pGL4-NFAT promoter AP1-luc assessed as inhibition of 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50533863(CHEMBL4593521)
Affinity DataIC50: 0.860nMAssay Description:Antagonist activity against human GnRH receptor expressed in human Chem1 cells assessed as inhibition of LHRH-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50533863(CHEMBL4593521)
Affinity DataIC50: 3.5nMAssay Description:Displacement of [125I]D-Trp6-LHRH from monkey GnRH receptor expressed in HEK293 cell membranes incubated for 1 hr by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50533863(CHEMBL4593521)
Affinity DataIC50: 1.60nMAssay Description:Antagonist activity against human GnRH receptor expressed in HEK293 cells co-transfected with pGL4-NFAT promoter AP1-luc assessed as inhibition of 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50533863(CHEMBL4593521)
Affinity DataIC50: 590nMAssay Description:Antagonist activity against rat GnRH receptor expressed in HEK293 cells co-transfected with pGL4-NFAT promoter AP1-luc assessed as inhibition of 1 nM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed