BDBM50533858 CHEMBL4449332

SMILES Cc1c(N2CCN(Cc3ccc(o3)C(F)(F)F)CC2)c(=O)n(C[C@H](NCCCC(O)=O)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F

InChI Key InChIKey=JLKXURLUTOXXPN-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50533858   

TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50533858(CHEMBL4449332)
Affinity DataIC50: 3.70nMAssay Description:Displacement of [125I]D-Trp6-LHRH from monkey GnRH receptor expressed in HEK293 cell membranes incubated for 1 hr by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50533858(CHEMBL4449332)
Affinity DataIC50: 520nMAssay Description:Displacement of [125I]D-Trp6-LHRH from rat GnRH receptor expressed in HEK293 cell membranes incubated for 1 hr by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50533858(CHEMBL4449332)
Affinity DataIC50: 0.760nMAssay Description:Antagonist activity against human GnRH receptor expressed in human Chem1 cells assessed as inhibition of LHRH-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50533858(CHEMBL4449332)
Affinity DataIC50: 279nMAssay Description:Antagonist activity against rat GnRH receptor expressed in HEK293 cells co-transfected with pGL4-NFAT promoter AP1-luc assessed as inhibition of 1 nM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50533858(CHEMBL4449332)
Affinity DataIC50: 13nMAssay Description:Antagonist activity against human GnRH receptor expressed in HEK293 cells co-transfected with pGL4-NFAT promoter AP1-luc assessed as inhibition of 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50533858(CHEMBL4449332)
Affinity DataIC50: 6.30nMAssay Description:Antagonist activity against human GnRH receptor expressed in HEK293 cells co-transfected with pGL4-NFAT promoter AP1-luc assessed as inhibition of 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50533858(CHEMBL4449332)
Affinity DataIC50: 13nMAssay Description:Antagonist activity against monkey GnRH receptor expressed in HEK293 cells co-transfected with pGL4-NFAT promoter AP1-luc assessed as inhibition of 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50533858(CHEMBL4449332)
Affinity DataIC50: 2.90nMAssay Description:Antagonist activity against human GnRH receptor expressed in HEK293 cells assessed as reduction in ERK1/2 phosphorylation pre-incubated for 5 mins be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50533858(CHEMBL4449332)
Affinity DataIC50: 0.440nMAssay Description:Displacement of [125I]D-Trp6-LHRH from human GnRH receptor expressed in CHO-K1 cell membranes incubated for 1 hr by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed