BDBM50533256 CHEMBL4448473

SMILES c1ccc(cc1)C(CNC(=O)[C@@H]2C[C@@H](CN2C(=O)c3ccc(cc3)CN)n4cc(nn4)C5CC5)c6ccccc6

InChI Key InChIKey=YBZBHUMSHGXQNF-UHFFFAOYSA-N

Data  12 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50533256   

TargetCoagulation factor X(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533256(CHEMBL4448473)
Affinity DataIC50: 7.10E+4nMAssay Description:Inhibition of human f10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProthrombin(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533256(CHEMBL4448473)
Affinity DataIC50: 9.40E+4nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533256(CHEMBL4448473)
Affinity DataIC50: 500nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cells measured after 90 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetChymotrypsinogen B2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533256(CHEMBL4448473)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human chymotrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533256(CHEMBL4448473)
Affinity DataIC50: 7.10E+4nMAssay Description:Inhibition of human f10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProthrombin(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533256(CHEMBL4448473)
Affinity DataIC50: 9.40E+4nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533256(CHEMBL4448473)
Affinity DataIC50: 500nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cells measured after 90 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533256(CHEMBL4448473)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533256(CHEMBL4448473)
Affinity DataIC50: 110nMAssay Description:Inhibition of human PRSS1 assessed as enzymatic cleavage of Benzoyl-GlyPro-Arg'Rh110-gammaGlu-OH by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533256(CHEMBL4448473)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533256(CHEMBL4448473)
Affinity DataIC50: 110nMAssay Description:Inhibition of human PRSS1 assessed as enzymatic cleavage of Benzoyl-GlyPro-Arg'Rh110-gammaGlu-OH by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetChymotrypsinogen B2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533256(CHEMBL4448473)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human chymotrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed