BDBM50533224 CHEMBL4474551

SMILES Cn1c2cnccc2n(-c2cc(nc3[nH]ccc23)-c2cc(Cl)ccc2F)c1=O

InChI Key InChIKey=HESAPDRVFTXZTE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50533224   

TargetCytochrome P450 3A4(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50533224(CHEMBL4474551)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50533224(CHEMBL4474551)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of ALK5 (unknown origin) using fluorescein-labeled peptide substrate incubated for 90 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50533224(CHEMBL4474551)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of ALK5 (unknown origin) using fluorescein-labeled peptide substrate incubated for 90 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50533224(CHEMBL4474551)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50533224(CHEMBL4474551)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50533224(CHEMBL4474551)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed