BDBM50533069 CHEMBL4077415

SMILES FC(F)(F)c1nnc2[C@H](N(CCn12)C(=O)c1cccc(c1Cl)C(F)(F)F)c1ccccc1

InChI Key InChIKey=OJHQUOGNBLXVTC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50533069   

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50533069(CHEMBL4077415)
Affinity DataIC50: 42nMAssay Description:Antagonist activity at rat P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50533069(CHEMBL4077415)
Affinity DataIC50: 42nMAssay Description:Antagonist activity at rat P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50533069(CHEMBL4077415)
Affinity DataIC50: 8.70nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50533069(CHEMBL4077415)
Affinity DataIC50: 8.70nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed