BDBM50532914 CHEMBL4293051

SMILES COc1cc(ccc1Nc1ncc2n(C(C)C)c(=O)c(=O)n(-c3cccc(NC(=O)C=C)c3)c2n1)N1CCN(C)CC1

InChI Key InChIKey=LDDDGIHXYBWEAR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50532914   

TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50532914(CHEMBL4293051)
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type EGFR kinase domain (unknown origin) expressed using baculovirus expression system incubated for 1 hr using Poly(Glu,Tyr) 4:1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50532914(CHEMBL4293051)
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type EGFR kinase domain (unknown origin) expressed using baculovirus expression system incubated for 1 hr using Poly(Glu,Tyr) 4:1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50532914(CHEMBL4293051)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of EGFR kinase domain L858R/T790M mutant (unknown origin) expressed using baculovirus expression system incubated for 1 hr using Poly(Glu,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50532914(CHEMBL4293051)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of EGFR kinase domain L858R/T790M mutant (unknown origin) expressed using baculovirus expression system incubated for 1 hr using Poly(Glu,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed