BDBM50532909 CHEMBL4527443

SMILES COc1cc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)ccc1N1CCN(CC1)C(C)=O

InChI Key InChIKey=YBWXACZKNLLYFI-UHFFFAOYSA-N

Data  4 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50532909   

TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50532909(CHEMBL4527443)
Affinity DataIC50: 20nMAssay Description:Inhibition of EGFR kinase domain L858R/T790M mutant (unknown origin) expressed using baculovirus expression system incubated for 1 hr using Poly(Glu,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50532909(CHEMBL4527443)
Affinity DataIC50: 272nMAssay Description:Inhibition of wild type EGFR kinase domain (unknown origin) expressed using baculovirus expression system incubated for 1 hr using Poly(Glu,Tyr) 4:1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50532909(CHEMBL4527443)
Affinity DataIC50: 20nMAssay Description:Inhibition of EGFR kinase domain L858R/T790M mutant (unknown origin) expressed using baculovirus expression system incubated for 1 hr using Poly(Glu,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50532909(CHEMBL4527443)
Affinity DataIC50: 272nMAssay Description:Inhibition of wild type EGFR kinase domain (unknown origin) expressed using baculovirus expression system incubated for 1 hr using Poly(Glu,Tyr) 4:1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50532909(CHEMBL4527443)
Affinity DataKi:  22nMAssay Description:Inhibition of EGFR kinase domain L858R/T790M mutant (unknown origin) by enzyme kinetic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50532909(CHEMBL4527443)
Affinity DataKi:  22nMAssay Description:Inhibition of EGFR kinase domain L858R/T790M mutant (unknown origin) by enzyme kinetic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50532909(CHEMBL4527443)
Affinity DataKi:  303nMAssay Description:Inhibition of wild type EGFR kinase domain (unknown origin) by enzyme kinetic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50532909(CHEMBL4527443)
Affinity DataKi:  303nMAssay Description:Inhibition of wild type EGFR kinase domain (unknown origin) by enzyme kinetic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed