BDBM50532759 CHEMBL4576381

SMILES Fc1ccc(cc1)-c1ccc2nnc(Sc3ccc4nc(NC(=O)CC5CC5)sc4c3)n2n1

InChI Key InChIKey=PYWIIDVJVPEJLN-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50532759   

TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532759(CHEMBL4576381)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of phosphorylated MET L1195V mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532759(CHEMBL4576381)
Affinity DataIC50: 13nMAssay Description:Inhibition of phosphorylated MET in human MKN45 cells assessed as reduction in pMET Y1230/1234/1235 level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532759(CHEMBL4576381)
Affinity DataIC50: 4nMAssay Description:Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532759(CHEMBL4576381)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of phosphorylated MET Y1230H mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532759(CHEMBL4576381)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of phosphorylated MET L1195V mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532759(CHEMBL4576381)
Affinity DataIC50: 13nMAssay Description:Inhibition of phosphorylated MET in human MKN45 cells assessed as reduction in pMET Y1230/1234/1235 level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532759(CHEMBL4576381)
Affinity DataIC50: 4nMAssay Description:Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532759(CHEMBL4576381)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of phosphorylated MET Y1230H mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532759(CHEMBL4576381)
Affinity DataIC50: 128nMAssay Description:Inhibition of phosphorylated MET M1250T mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532759(CHEMBL4576381)
Affinity DataIC50: 128nMAssay Description:Inhibition of phosphorylated MET M1250T mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed