BDBM50532752 CHEMBL4459929

SMILES CCN(CC)CCNC(=O)Nc1nc2ccc(Sc3nnc4ccc(nn34)-c3ccc(F)cc3)cc2s1

InChI Key InChIKey=KWWVEGSNWIJWMP-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50532752   

TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532752(CHEMBL4459929)
Affinity DataIC50: 10nMAssay Description:Inhibition of phosphorylated MET in human MKN45 cells assessed as reduction in pMET Y1230/1234/1235 level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532752(CHEMBL4459929)
Affinity DataIC50: 10nMAssay Description:Inhibition of phosphorylated MET in human MKN45 cells assessed as reduction in pMET Y1230/1234/1235 level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532752(CHEMBL4459929)
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532752(CHEMBL4459929)
Affinity DataIC50: 148nMAssay Description:Inhibition of phosphorylated MET L1195V mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532752(CHEMBL4459929)
Affinity DataIC50: 71nMAssay Description:Inhibition of phosphorylated MET M1250T mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532752(CHEMBL4459929)
Affinity DataIC50: 148nMAssay Description:Inhibition of phosphorylated MET L1195V mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532752(CHEMBL4459929)
Affinity DataIC50: 71nMAssay Description:Inhibition of phosphorylated MET M1250T mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532752(CHEMBL4459929)
Affinity DataIC50: 864nMAssay Description:Inhibition of phosphorylated MET Y1230H mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532752(CHEMBL4459929)
Affinity DataIC50: 864nMAssay Description:Inhibition of phosphorylated MET Y1230H mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532752(CHEMBL4459929)
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed