BDBM50532742 CHEMBL4455063

SMILES CC1=C(CC(=O)NCc2cc(Cl)ccc2CN)C(=O)N(CC1)NCc1ccccc1

InChI Key InChIKey=YWFMRWMBBNBQMO-UHFFFAOYSA-N

Data  12 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50532742   

TargetCytochrome P450 3A4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50532742(CHEMBL4455063)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50532742(CHEMBL4455063)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProthrombin(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50532742(CHEMBL4455063)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human alpha-thrombin using S-2366 as substrate after 40 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProthrombin(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50532742(CHEMBL4455063)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human alpha-thrombin using S-2366 as substrate after 40 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50532742(CHEMBL4455063)
Affinity DataKi: >5.40E+3nMAssay Description:Inhibition of human trypsin 1 using S-2222 as substrate preincubated for 300 secs followed by substrate addition measured after 40 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50532742(CHEMBL4455063)
Affinity DataKi: >5.40E+3nMAssay Description:Inhibition of human trypsin 1 using S-2222 as substrate preincubated for 300 secs followed by substrate addition measured after 40 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50532742(CHEMBL4455063)
Affinity DataKi: >1.70E+4nMAssay Description:Inhibition of human F10a using S-2765 as substrate preincubated for 300 secs followed by substrate addition measured after 40 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50532742(CHEMBL4455063)
Affinity DataKi: >1.70E+4nMAssay Description:Inhibition of human F10a using S-2765 as substrate preincubated for 300 secs followed by substrate addition measured after 40 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50532742(CHEMBL4455063)
Affinity DataKi: >1.90E+4nMAssay Description:Inhibition of human F11a using S-2366 as substrate preincubated for 300 secs followed by substrate addition measured after 40 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50532742(CHEMBL4455063)
Affinity DataKi: >1.90E+4nMAssay Description:Inhibition of human F11a using S-2366 as substrate preincubated for 300 secs followed by substrate addition measured after 40 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPlasminogen(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50532742(CHEMBL4455063)
Affinity DataKi: >1.90E+4nMAssay Description:Inhibition of human plasmin using S-2366 as substrate preincubated for 300 secs followed by substrate addition measured after 40 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPlasminogen(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50532742(CHEMBL4455063)
Affinity DataKi: >1.90E+4nMAssay Description:Inhibition of human plasmin using S-2366 as substrate preincubated for 300 secs followed by substrate addition measured after 40 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCoagulation factor IX(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50532742(CHEMBL4455063)
Affinity DataKi: >2.90E+4nMAssay Description:Inhibition of human F9a using pefachrome F9a as substrate preincubated for 300 secs followed by substrate addition measured after 40 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCoagulation factor IX(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50532742(CHEMBL4455063)
Affinity DataKi: >2.90E+4nMAssay Description:Inhibition of human F9a using pefachrome F9a as substrate preincubated for 300 secs followed by substrate addition measured after 40 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed