BDBM50531949 CHEMBL4452034

SMILES CCN(CC)[C@@H](C(=O)N1C[C@H](F)C[C@H]1c1ncc([nH]1)-c1ccc2c(ccc3oc4cc(ccc4c(=O)c23)-c2cnc([nH]2)[C@@H]2C[C@@H](F)CN2C(=O)[C@H](N(CC)CC)c2ccccc2)c1)c1ccccc1

InChI Key InChIKey=KVGZMEGPCWHQJL-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50531949   

TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50531949(CHEMBL4452034)
Affinity DataEC50:  0.0260nMAssay Description:Inhibition of NS5A in HCV genotype 3a assessed as decrease in viral replicationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50531949(CHEMBL4452034)
Affinity DataEC50:  0.310nMAssay Description:Inhibition of NS5A in HCV genotype 1a assessed as decrease in viral replicationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50531949(CHEMBL4452034)
Affinity DataEC50:  506nMAssay Description:Inhibition of NS5A Y93H mutant in HCV genotype 1a assessed as decrease in viral replicationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50531949(CHEMBL4452034)
Affinity DataEC50:  797nMAssay Description:Inhibition of NS5A in HCV genotype 2b assessed as decrease in viral replicationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed