BDBM50531795 CHEMBL4552468

SMILES Nc1ncc(N2CCN(CC2)c2ccc(cc2)-c2ccccc2)c(N)n1

InChI Key InChIKey=ZATFHERBDAPYGH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50531795   

TargetDihydrofolate reductase(Human)
Vyera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50531795(CHEMBL4552468)
Affinity DataIC50: 347nMAssay Description:Inhibition of human DHFR expressed in Escherichia coli BL21 competent cells using DHF as substrate preincubated for 15 mins followed by substrate and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Vyera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50531795(CHEMBL4552468)
Affinity DataIC50: 32nMAssay Description:Inhibition of Toxoplasma gondii DHFR-TS expressed in Escherichia coli BL21 competent cells using DHF as substrate preincubated for 15 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed