BDBM50531569 CHEMBL4532472

SMILES c1cc2c(cc1C(=O)N3c4ccc(cc4OC[C@@H]3CS(=O)(=O)N)F)NC(=O)CO2

InChI Key InChIKey=FDWPXNLUFQNWMH-UHFFFAOYSA-N

Data  2 KI  4 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50531569   

TargetMineralocorticoid receptor(Rat)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50531569(CHEMBL4532472)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at gal4-fused rat mineralocorticoid receptor LBD in expressed in human U2OS cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMineralocorticoid receptor(Human)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50531569(CHEMBL4532472)
Affinity DataEC50:  0.0501nMAssay Description:Modulation activity at human mineralocorticoid receptor in human EA.hy926 cells assessed as induction of nuclear translocation of mineralocorticoid r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMineralocorticoid receptor(Human)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50531569(CHEMBL4532472)
Affinity DataIC50: 32nMAssay Description:Antagonist activity at full length human mineralocorticoid receptor expressed in human U2OS cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMineralocorticoid receptor(Human)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50531569(CHEMBL4532472)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at gal4-fused human mineralocorticoid receptor LBD expressed in UAS-MR-bla HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMineralocorticoid receptor(Human)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50531569(CHEMBL4532472)
Affinity DataIC50: 1.00E+4nMAssay Description:Modulation activity at human mineralocorticoid receptor in human EA.hy926 cells assessed as blocking of nuclear translocation of mineralocorticoid re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMineralocorticoid receptor(Human)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50531569(CHEMBL4532472)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]-aldosterone to human mineralocorticoid receptor LBD by radiometric binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Human)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50531569(CHEMBL4532472)
Affinity DataKi:  251nMAssay Description:Binding affinity to recombinant human GR LBD by fluormone GS red-fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed