BDBM50531539 CHEMBL4283519

SMILES COc1ccc(NC(=O)COc2ccc(cc2)C(=O)\C=C\c2cc(OC)c(OC)c(OC)c2)cc1OC

InChI Key InChIKey=KRBVAHJAUKYLQU-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50531539   

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Rheinische Friedrich-Wilhelms-University of Bonn

Curated by ChEMBL
LigandPNGBDBM50531539(CHEMBL4283519)
Affinity DataEC50:  107nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in MDCK2 cells co-expressing BCRP (unknown origin) assessed as potentiation of SN-38-induced cytotoxic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Rheinische Friedrich-Wilhelms-University of Bonn

Curated by ChEMBL
LigandPNGBDBM50531539(CHEMBL4283519)
Affinity DataIC50: 3.37E+3nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in MDCK II BCRP cells assessed as effect on pheophorbide A accumulation after 120 mins by flow cytomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Rheinische Friedrich-Wilhelms-University of Bonn

Curated by ChEMBL
LigandPNGBDBM50531539(CHEMBL4283519)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of ABCC1 in human H96AR cells preincubated for 30 mins followed by calcein AM addition and measured every 60 secs for 1 hr by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed