BDBM50531329 CHEMBL4082995

SMILES ONC(=O)\C=C\c1cccn(CCCc2ccc3ccccc3c2)c1=O

InChI Key InChIKey=KYXMKYJAKNUUDF-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50531329   

TargetHistone deacetylase 2(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50531329(CHEMBL4082995)
Affinity DataIC50: 128nMAssay Description:Inhibition of recombinant full-length human HDAC2 using RHKK(Ac) as substrate measured after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50531329(CHEMBL4082995)
Affinity DataIC50: 1.93E+3nMAssay Description:Inhibition of recombinant full-length human HDAC5 using Boc-Lys(trifluoroacetyl)-AMC as substrate measured after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50531329(CHEMBL4082995)
Affinity DataIC50: 3.72E+3nMAssay Description:Inhibition of recombinant full-length human HDAC7 using Boc-Lys(trifluoroacetyl)-AMC as substrate measured after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50531329(CHEMBL4082995)
Affinity DataIC50: 5.58E+3nMAssay Description:Inhibition of recombinant full-length human HDAC9 using Boc-Lys(trifluoroacetyl)-AMC as substrate measured after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50531329(CHEMBL4082995)
Affinity DataIC50: 55nMAssay Description:Inhibition of recombinant full-length human HDAC11 using RHKK(Ac) as substrate measured after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50531329(CHEMBL4082995)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant full-length human HDAC1 using RHKK(Ac) as substrate measured after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50531329(CHEMBL4082995)
Affinity DataIC50: 331nMAssay Description:Inhibition of recombinant full-length human HDAC3/NCOR2 using RHKK(Ac) as substrate measured after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50531329(CHEMBL4082995)
Affinity DataIC50: 5.73E+3nMAssay Description:Inhibition of recombinant full-length human HDAC4 using Boc-Lys(trifluoroacetyl)-AMC as substrate measured after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50531329(CHEMBL4082995)
Affinity DataIC50: 52nMAssay Description:Inhibition of recombinant full-length human HDAC10 using RHKK(Ac) as substrate measured after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50531329(CHEMBL4082995)
Affinity DataIC50: 188nMAssay Description:Inhibition of recombinant full-length human HDAC8 using RHKK(Ac) as substrate measured after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50531329(CHEMBL4082995)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant full-length human HDAC6 using RHKK(Ac) as substrate measured after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50531329(CHEMBL4082995)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human full-length recombinant HDAC6 using fluorogenic peptide 79-382 (RHKK(Ac)) as substrate by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50531329(CHEMBL4082995)
Affinity DataIC50: 19nMAssay Description:Inhibition of human full-length recombinant HDAC1 using p53 fluorogenic peptide (79 to 382 residues) (RHKK(Ac)) as substrate by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50531329(CHEMBL4082995)
Affinity DataIC50: 128nMAssay Description:Inhibition of human full-length recombinant HDAC2 using fluorogenic peptide (79 to 382 residues) (RHKK(Ac)) as substrate by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50531329(CHEMBL4082995)
Affinity DataIC50: 70nMAssay Description:Inhibition of HDAC in human HeLa cell extracts using Fluor de lys as substrate incubated for 30 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed