BDBM50531013 CHEMBL4453121

SMILES ONC(=O)c1ccc(Cn2nnc(n2)-c2ncccn2)cc1

InChI Key InChIKey=PMHARNDBRDSPAO-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50531013   

TargetHistone deacetylase 6(Human)
Preclinical R&D

Curated by ChEMBL
LigandPNGBDBM50531013(CHEMBL4453121)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 insect cells pretreated with compound f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Preclinical R&D

Curated by ChEMBL
LigandPNGBDBM50531013(CHEMBL4453121)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 insect cells pretreated with compound f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Italfarmaco

Curated by ChEMBL
LigandPNGBDBM50531013(CHEMBL4453121)
Affinity DataIC50: 930nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC1 expressed in Sf9 insect cells using Fluor de Lys deacetylase or Fluor de Lys Green deacet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Preclinical R&D

Curated by ChEMBL
LigandPNGBDBM50531013(CHEMBL4453121)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in Sf9 insect cells using Fluor de Lys deacetylase or Fluor de Lys ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Italfarmaco

Curated by ChEMBL
LigandPNGBDBM50531013(CHEMBL4453121)
Affinity DataIC50: 3.01E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC2 (1 to 488 residues) expressed in Sf9 insect cells using Fluor de Lys deacetylase or Fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Italfarmaco

Curated by ChEMBL
LigandPNGBDBM50531013(CHEMBL4453121)
Affinity DataIC50: 884nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC3 (1 to 428 residues) expressed in Sf9 insect cells using Fluor de Lys deacetylase or Fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Italfarmaco

Curated by ChEMBL
LigandPNGBDBM50531013(CHEMBL4453121)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged and C-terminal His-tagged HDAC4 (627 to 1084 residues) expressed in Sf9 insect cells using Neps...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
Italfarmaco

Curated by ChEMBL
LigandPNGBDBM50531013(CHEMBL4453121)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human ful length N-terminal GST-tagged HDAC5 expressed in baculovirus expression system using Nepsilon-Trifluoroacetyl L-ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
Italfarmaco

Curated by ChEMBL
LigandPNGBDBM50531013(CHEMBL4453121)
Affinity DataIC50: 1.01E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HDAC7 (518 to end residues) expressed in baculovirus expression system using Nepsilon-Trifluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Italfarmaco

Curated by ChEMBL
LigandPNGBDBM50531013(CHEMBL4453121)
Affinity DataIC50: 320nMAssay Description:Inhibition of recombinant human full length C-terminal His-tagged HDAC8 expressed in baculovirus expression system using Fluor de Lys deacetylase or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
Italfarmaco

Curated by ChEMBL
LigandPNGBDBM50531013(CHEMBL4453121)
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC9 (604 to 1066 residues) expressed in baculovirus expression system using Nepsilon-Trifluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
Italfarmaco

Curated by ChEMBL
LigandPNGBDBM50531013(CHEMBL4453121)
Affinity DataIC50: 474nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged HDAC10 (1 to 613 residues) expressed in Sf9 insect cells using Fluor de Lys deacetylase or Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
Italfarmaco

Curated by ChEMBL
LigandPNGBDBM50531013(CHEMBL4453121)
Affinity DataIC50: 762nMAssay Description:Inhibition of recombinant human N-terminal His-tagged HDAC11 expressed in baculovirus expression system using Fluor de Lys deacetylase or Fluor de Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed