BDBM50530788 CHEMBL4460058

SMILES C[C@H](c1ccc(F)cn1)n1c2nc(Nc3cc(Cl)c[nH]c3=O)ncc2[nH]c1=O

InChI Key InChIKey=RGNIUSWPXKKEQI-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50530788   

TargetTyrosine-protein kinase JAK2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530788(CHEMBL4460058)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human N-terminal His-tagged JAK2 (826 to 1132 residues) expressed in baculovirus expression system using PolyGT-Biotin as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530788(CHEMBL4460058)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human N-terminal His-tagged JAK2 (826 to 1132 residues) expressed in baculovirus expression system using PolyGT-Biotin as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetJAK3/JAK1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530788(CHEMBL4460058)
Affinity DataIC50: 68nMAssay Description:Inhibition of JAK1/3 in human Ramos cells harboring beta-lactamase reporter gene assessed as reduction in IL4-induced STAT6 phosphorylation incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530788(CHEMBL4460058)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in Sf1 cells using PolyGT-Biotin as substrate measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530788(CHEMBL4460058)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human GST-tagged JAK1 (866 to 1154 residues) expressed in baculovirus expression system using PolyGT-Biotin as substrate me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530788(CHEMBL4460058)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in Sf1 cells using PolyGT-Biotin as substrate measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetJAK3/JAK1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530788(CHEMBL4460058)
Affinity DataIC50: 68nMAssay Description:Inhibition of JAK1/3 in human Ramos cells harboring beta-lactamase reporter gene assessed as reduction in IL4-induced STAT6 phosphorylation incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530788(CHEMBL4460058)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human GST-tagged JAK1 (866 to 1154 residues) expressed in baculovirus expression system using PolyGT-Biotin as substrate me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed