BDBM50530383 CHEMBL4530719

SMILES CS(=O)(=O)c1ccccc1Nc1cc(Nc2ccc(F)cn2)ncc1C(N)=O

InChI Key InChIKey=KTGJVACKWAPPPX-UHFFFAOYSA-N

Data  20 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50530383   

LigandPNGBDBM50530383(CHEMBL4530719)
Affinity DataIC50: 35nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530383(CHEMBL4530719)
Affinity DataIC50: 83nMAssay Description:Inhibition of TYK2 JH2 domain in mouse whole blood assessed as inhibition of IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530383(CHEMBL4530719)
Affinity DataIC50: 33nMAssay Description:Inhibition of TYK2 JH2 domain in human whole blood assessed as inhibition of IFNalpha-induced STAT5 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530383(CHEMBL4530719)
Affinity DataIC50: 260nMAssay Description:Inhibition of JAK1/JAK2 (unknown origin) in GM-CSF stimulated cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530383(CHEMBL4530719)
Affinity DataIC50: 35nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530383(CHEMBL4530719)
Affinity DataIC50: 43nMAssay Description:Inhibition of JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530383(CHEMBL4530719)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetJAK3/JAK1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530383(CHEMBL4530719)
Affinity DataIC50: 960nMAssay Description:Inhibition of JAK1/JAK3 (unknown origin) in IL-2 stimulated cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530383(CHEMBL4530719)
Affinity DataIC50: 43nMAssay Description:Inhibition of JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530383(CHEMBL4530719)
Affinity DataIC50: 260nMAssay Description:Inhibition of JAK1/JAK2 (unknown origin) in GM-CSF stimulated cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530383(CHEMBL4530719)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530383(CHEMBL4530719)
Affinity DataIC50: 46nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530383(CHEMBL4530719)
Affinity DataIC50: 18nMAssay Description:Inhibition of JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530383(CHEMBL4530719)
Affinity DataIC50: 42nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530383(CHEMBL4530719)
Affinity DataIC50: 42nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetJAK3/JAK1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530383(CHEMBL4530719)
Affinity DataIC50: 960nMAssay Description:Inhibition of JAK1/JAK3 (unknown origin) in IL-2 stimulated cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530383(CHEMBL4530719)
Affinity DataIC50: 18nMAssay Description:Inhibition of JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530383(CHEMBL4530719)
Affinity DataIC50: 46nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530383(CHEMBL4530719)
Affinity DataIC50: 83nMAssay Description:Inhibition of TYK2 JH2 domain in mouse whole blood assessed as inhibition of IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530383(CHEMBL4530719)
Affinity DataIC50: 33nMAssay Description:Inhibition of TYK2 JH2 domain in human whole blood assessed as inhibition of IFNalpha-induced STAT5 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed