BDBM50530247 CHEMBL4459445::US10975080, Example 20

SMILES Cn1c(nc2[nH]nc(-c3cccc(Cl)c3Cl)c2c1=O)N1CCC2(COC[C@H]2N)CC1

InChI Key InChIKey=KOFLHKSEIMZJFM-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50530247   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530247(CHEMBL4459445 | US10975080, Example 20)
Affinity DataIC50: 930nMAssay Description:Inhibition of human ERG by Q-patch assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530247(CHEMBL4459445 | US10975080, Example 20)
Affinity DataIC50: 50nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530247(CHEMBL4459445 | US10975080, Example 20)
Affinity DataIC50: 123nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530247(CHEMBL4459445 | US10975080, Example 20)
Affinity DataIC50: 50nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530247(CHEMBL4459445 | US10975080, Example 20)
Affinity DataIC50: 123nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530247(CHEMBL4459445 | US10975080, Example 20)
Affinity DataIC50: 930nMAssay Description:Inhibition of human ERG by Q-patch assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530247(CHEMBL4459445 | US10975080, Example 20)
Affinity DataIC50: 50nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phosphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
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