BDBM50530020 CHEMBL4469773

SMILES CC(C)OC(=O)[C@H](C)N[P@@](=O)(OC[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@](F)(Br)[C@H]1O)Oc1ccccc1

InChI Key InChIKey=ZTJBRLHJSDGEDC-UHFFFAOYSA-N

Data  2 IC50  14 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50530020   

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50530020(CHEMBL4469773)
Affinity DataEC50:  160nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 2a infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50530020(CHEMBL4469773)
Affinity DataEC50:  120nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1a infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50530020(CHEMBL4469773)
Affinity DataEC50:  160nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 2a infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50530020(CHEMBL4469773)
Affinity DataEC50:  230nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b/3a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50530020(CHEMBL4469773)
Affinity DataEC50:  170nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b/4a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50530020(CHEMBL4469773)
Affinity DataEC50:  210nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b/5a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50530020(CHEMBL4469773)
Affinity DataEC50:  700nMAssay Description:Inhibition of NS5B polymerase in wild type HCV genotype 1b infected in human Huh7 replicon cells after 5 days by RT-PCR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50530020(CHEMBL4469773)
Affinity DataEC50:  230nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b/3a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50530020(CHEMBL4469773)
Affinity DataEC50:  210nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b/5a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50530020(CHEMBL4469773)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50530020(CHEMBL4469773)
Affinity DataEC50:  120nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1a infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50530020(CHEMBL4469773)
Affinity DataEC50:  700nMAssay Description:Inhibition of NS5B polymerase in wild type HCV genotype 1b infected in human Huh7 replicon cells after 5 days by RT-PCR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50530020(CHEMBL4469773)
Affinity DataEC50:  3.60E+3nMAssay Description:Inhibition of NS5B polymerase S282T mutant in HCV genotype 1b infected in human Huh7 replicon cells after 5 days by RT-PCR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50530020(CHEMBL4469773)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50530020(CHEMBL4469773)
Affinity DataEC50:  170nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b/4a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50530020(CHEMBL4469773)
Affinity DataEC50:  3.60E+3nMAssay Description:Inhibition of NS5B polymerase S282T mutant in HCV genotype 1b infected in human Huh7 replicon cells after 5 days by RT-PCR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed