BDBM50529938 CHEMBL259388

SMILES [#6]-c1nc2sccn2c(=O)c1-[#6]-[#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6](\c1ccccc1)-c1ccc(F)cc1

InChI Key InChIKey=IMEOPKDCRSSTMZ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50529938   

TargetDiacylglycerol kinase alpha(Pig)
University of Piemonte Orientale

Curated by ChEMBL
LigandPNGBDBM50529938(CHEMBL259388)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of pig FLAG3-tagged DGKalpha expressed in African green monkey COS7 cells using 1,2-dioleoyl-sn-glycerol as substrate measured after 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetDiacylglycerol kinase alpha(Human)
University of Piemonte Orientale

Curated by ChEMBL
LigandPNGBDBM50529938(CHEMBL259388)
Affinity DataIC50: 1.97E+4nMAssay Description:Inhibition of OST-tagged DGKalpha (unknown origin) expressed in MDCK cell homogenates using DAG as substrate measured after 5 mins in presence of [ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetDiacylglycerol kinase alpha(Rat)
University of Piemonte Orientale

Curated by ChEMBL
LigandPNGBDBM50529938(CHEMBL259388)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of rat FLAG-tagged DGKalpha expressed in HEK293T cells using DAG as substrate measured after 15 mins in presence of [gamma-32P]ATP by scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetDiacylglycerol kinase alpha(Human)
University of Piemonte Orientale

Curated by ChEMBL
LigandPNGBDBM50529938(CHEMBL259388)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of DGKalpha in human erythrocytes using OAG as substrate preincubated for 1 min followed by OAG addition and measured after 8 mins in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetDiacylglycerol kinase alpha(Rat)
University of Piemonte Orientale

Curated by ChEMBL
LigandPNGBDBM50529938(CHEMBL259388)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of rat FLAG-tagged DGKalpha expressed in HEK293T cells using DAG as substrate measured after 15 mins in presence of [gamma-32P]ATP by scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetDiacylglycerol kinase alpha(Human)
University of Piemonte Orientale

Curated by ChEMBL
LigandPNGBDBM50529938(CHEMBL259388)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of DGKalpha in human erythrocytes using OAG as substrate preincubated for 1 min followed by OAG addition and measured after 8 mins in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetDiacylglycerol kinase alpha(Pig)
University of Piemonte Orientale

Curated by ChEMBL
LigandPNGBDBM50529938(CHEMBL259388)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of pig FLAG3-tagged DGKalpha expressed in African green monkey COS7 cells using 1,2-dioleoyl-sn-glycerol as substrate measured after 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetDiacylglycerol kinase alpha(Human)
University of Piemonte Orientale

Curated by ChEMBL
LigandPNGBDBM50529938(CHEMBL259388)
Affinity DataIC50: 1.97E+4nMAssay Description:Inhibition of OST-tagged DGKalpha (unknown origin) expressed in MDCK cell homogenates using DAG as substrate measured after 5 mins in presence of [ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetDiacylglycerol kinase alpha(Human)
University of Piemonte Orientale

Curated by ChEMBL
LigandPNGBDBM50529938(CHEMBL259388)
Affinity DataIC50: 2.54E+4nMAssay Description:Inhibition of DGK alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed