BDBM50529897 CHEMBL4468383

SMILES O[C@@H](CNC(=O)c1ccc2CN(CCc2c1)C(=O)c1ccc(Br)cc1)CN1CCc2ccccc2C1

InChI Key InChIKey=VFSOQQVDAIJQES-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50529897   

TargetProtein arginine N-methyltransferase 7(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant full length human N-terminal FLAG-tagged PRMT7 expressed in Sf9 insect cells preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 3(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human N-terminal GST-tagged PRMT3 (2 to end residues) expressed in Escherichia coli preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 7(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant full length human N-terminal FLAG-tagged PRMT7 expressed in Sf9 insect cells preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 8(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human N-terminal His/FLAG-tagged PRMT8 (61 to 394 residues) expressed in baculovirus infected Sf9 insect cells preincubated for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 3(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human N-terminal GST-tagged PRMT3 (2 to end residues) expressed in Escherichia coli preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human N-terminal FLAG-tagged PRMT4 (2 to end residues) expressed in FreeStyle 293-F cells preincubated for 15 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human N-terminal GST-tagged PRMT1 (2 to end residues) expressed in baculovirus infected Sf9 insect cells preincubated for 15 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human N-terminal His-tagged PRMT6 (2 to 375 residues) expressed in Escherichia coli preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human N-terminal His-tagged PRMT6 (2 to 375 residues) expressed in Escherichia coli preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 8(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human N-terminal His/FLAG-tagged PRMT8 (61 to 394 residues) expressed in baculovirus infected Sf9 insect cells preincubated for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human N-terminal FLAG-tagged PRMT4 (2 to end residues) expressed in FreeStyle 293-F cells preincubated for 15 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human N-terminal GST-tagged PRMT1 (2 to end residues) expressed in baculovirus infected Sf9 insect cells preincubated for 15 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
University of Jinan

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed