BDBM50529867 CHEMBL4529961

SMILES COc1cc2CCN(Cc3ccc(cc3)-c3ccc4NC(=O)C(N5CCc6cc(OC)c(OC)cc6C5)c4c3)Cc2cc1OC

InChI Key InChIKey=JGNNWOOKUPBSON-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50529867   

TargetATP-dependent translocase ABCB1(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50529867(CHEMBL4529961)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as increase in calcein-AM accumulation after 30 mins by calcein-AM dye based flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50529867(CHEMBL4529961)
Affinity DataEC50:  1.80E+3nMAssay Description:Inhibition of BCRP (unknown origin) expressed in MDCK cells assessed as reduction in Hoechst 33342 efflux preincubated for 30 mins followed by Hoechs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50529867(CHEMBL4529961)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as increase in calcein-AM accumulation after 30 mins by calcein-AM dye based flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50529867(CHEMBL4529961)
Affinity DataEC50:  1.80E+3nMAssay Description:Inhibition of BCRP (unknown origin) expressed in MDCK cells assessed as reduction in Hoechst 33342 efflux preincubated for 30 mins followed by Hoechs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed