BDBM50529860 CHEMBL4474280

SMILES CCCCNC(=O)Nc1ccc(cc1)-c1ccc(CN2CCc3cc(OC)c(OC)cc3C2)cc1

InChI Key InChIKey=LXFYAANLQKZEQU-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50529860   

TargetATP-dependent translocase ABCB1(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50529860(CHEMBL4474280)
Affinity DataEC50:  320nMAssay Description:Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as increase in calcein-AM accumulation after 30 mins by calcein-AM dye based flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50529860(CHEMBL4474280)
Affinity DataEC50:  4.60E+4nMAssay Description:Inhibition of BCRP (unknown origin) expressed in MDCK cells assessed as reduction in Hoechst 33342 efflux preincubated for 30 mins followed by Hoechs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50529860(CHEMBL4474280)
Affinity DataEC50:  320nMAssay Description:Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as increase in calcein-AM accumulation after 30 mins by calcein-AM dye based flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50529860(CHEMBL4474280)
Affinity DataEC50:  4.60E+4nMAssay Description:Inhibition of BCRP (unknown origin) expressed in MDCK cells assessed as reduction in Hoechst 33342 efflux preincubated for 30 mins followed by Hoechs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed