BDBM50529667 CHEMBL4444904::US10806720, Compound 11::US11230523, Compound 11::US11648234, Compound 11

SMILES C[C@](O)(Cn1ccc2cc(F)ccc12)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F

InChI Key InChIKey=CFSAYQVTXBMPRF-UHFFFAOYSA-N

Data  10 KI  7 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50529667   

TargetAndrogen receptor(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50529667(CHEMBL4444904 | US10806720, Compound 11 | US112305...)
Affinity DataIC50: 85nMAssay Description:Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of R1881-induced receptor transactivation after 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50529667(CHEMBL4444904 | US10806720, Compound 11 | US112305...)
Affinity DataIC50: 6.10nMAssay Description:Antagonist activity at AR F876L mutant (unknown origin) expressed in COS cells co-transfected with GRE-LUC and CMV-renilla LUC assessed as inhibition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetAndrogen receptor(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50529667(CHEMBL4444904 | US10806720, Compound 11 | US112305...)
Affinity DataIC50: 85.1nMAssay Description:Methods: hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

TargetAndrogen receptor(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50529667(CHEMBL4444904 | US10806720, Compound 11 | US112305...)
Affinity DataKd:  1.30E+3nMAssay Description:Inhibition of androgen receptor AF1 domain (141 to 486 residues) (unknown origin) incubated for 30 mins by steady-state fluorescence emission spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50529667(CHEMBL4444904 | US10806720, Compound 11 | US112305...)
Affinity DataIC50: 85nMAssay Description:Antagonist activity at CMV-tagged full length wild type human AR expressed in HEK293 cells co-transfected with GRE-LUC and CMV-renilla LUC assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetAndrogen receptor(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50529667(CHEMBL4444904 | US10806720, Compound 11 | US112305...)
Affinity DataIC50: 85nMAssay Description:Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of R1881-induced receptor transactivation after 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50529667(CHEMBL4444904 | US10806720, Compound 11 | US112305...)
Affinity DataIC50: 85nMAssay Description:Antagonist activity at human androgen receptor expressed in HEK-293 cells harboring GRE-LUC and CMV-renilla luciferase assessed as inhibition of tran...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetAndrogen receptor [633-919](Human)
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM50529667(CHEMBL4444904 | US10806720, Compound 11 | US112305...)
Affinity DataIC50: 85.1nMAssay Description:Methods: hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
Go to US Patent

TargetAndrogen receptor(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50529667(CHEMBL4444904 | US10806720, Compound 11 | US112305...)
Affinity DataKi:  78nMAssay Description:Displacement of [3H]-mibolerone from GST-tagged human AR-LBD expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Rat)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50529667(CHEMBL4444904 | US10806720, Compound 11 | US112305...)
Affinity DataKi:  267nMAssay Description:Inhibition of [3H] MIB binding to rat prostate androgen receptor LBD by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50529667(CHEMBL4444904 | US10806720, Compound 11 | US112305...)
Affinity DataKi:  267nMAssay Description:Binding affinity to GST tagged AR LBD (unknown orign) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetAndrogen receptor(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50529667(CHEMBL4444904 | US10806720, Compound 11 | US112305...)
Affinity DataKi:  267nMAssay Description:Displacement of [3H]mibolerone from GST-tagged wild type AR ligand binding domain (unknown origin) incubated for 16 hrs by scintillation counting ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetAndrogen receptor [633-919](Human)
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM50529667(CHEMBL4444904 | US10806720, Compound 11 | US112305...)
Affinity DataKi:  267nMAssay Description:Methods: hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
Go to US Patent

TargetAndrogen receptor [633-919](Human)
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM50529667(CHEMBL4444904 | US10806720, Compound 11 | US112305...)
Affinity DataKi:  267nMAssay Description:hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD was combin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2022
Entry Details
Go to US Patent

TargetAndrogen receptor(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50529667(CHEMBL4444904 | US10806720, Compound 11 | US112305...)
Affinity DataKi:  267nMAssay Description:Methods: hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

TargetAndrogen receptor(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50529667(CHEMBL4444904 | US10806720, Compound 11 | US112305...)
Affinity DataKi:  267nMAssay Description:Displacement of [3H]-mibolerone from recombinant wild-type GST-tagged androgen receptor LBD (unknown origin) after 16 hrs by scintillation counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50529667(CHEMBL4444904 | US10806720, Compound 11 | US112305...)
Affinity DataKi:  267nMAssay Description:Displacement of [3H]-mibolerone from recombinant wild-type GST-tagged androgen receptor LBD (unknown origin) after 16 hrs by scintillation counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetAndrogen receptor(Rat)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50529667(CHEMBL4444904 | US10806720, Compound 11 | US112305...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to rat Androgen receptor ligand binding domain measured by competitive ligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed