BDBM50529556 CHEMBL4552313

SMILES C[C@H]1CCCN1Cc1nc2cc(NC(=O)c3ccc4n(C)ncc4c3)ccc2[nH]1

InChI Key InChIKey=QGNDVASWIHEXCL-UHFFFAOYSA-N

Data  7 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50529556   

TargetProtein ENL(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50529556(CHEMBL4552313)
Affinity DataIC50: 260nMAssay Description:Inhibition of human MLLT1 by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProtein ENL(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50529556(CHEMBL4552313)
Affinity DataKd:  113nMAssay Description:Binding affinity to human MLLT1 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProtein ENL(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50529556(CHEMBL4552313)
Affinity DataIC50: 18nMAssay Description:Inhibition of His6-tagged ENL YEATS domain (unknown origin) expressed in Escherichia coli BL21 DE3 and biotinylated H3K27ac peptide interaction using...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetProtein AF-9(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50529556(CHEMBL4552313)
Affinity DataIC50: 600nMAssay Description:Binding affinity to MLLT3 in human HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetProtein ENL(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50529556(CHEMBL4552313)
Affinity DataIC50: 14nMAssay Description:Inhibition of C-terminal 6xHis-tagged ENL YEATS domain (1 to 148 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using bioti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProtein ENL(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50529556(CHEMBL4552313)
Affinity DataKd:  25nMAssay Description:Binding affinity to C-terminal 6xHis-tagged ENL YEATS domain (1 to 148 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells asses...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProtein ENL(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50529556(CHEMBL4552313)
Affinity DataIC50: 260nMAssay Description:Inhibition of wild type human ENL YEATS domain by Alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProtein ENL(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50529556(CHEMBL4552313)
Affinity DataKd:  129nMAssay Description:Binding affinity to wild type human ENL YEATS domain assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProtein ENL(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50529556(CHEMBL4552313)
Affinity DataIC50: 120nMAssay Description:Inhibition of 5x6His-tagged ENL YEATS domain (unknown origin) using biotinylated peptide H3K9cr (1 to 20 residues) preincubated for 15 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProtein ENL(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50529556(CHEMBL4552313)
Affinity DataKd:  100nMAssay Description:Binding affinity to ENL YEATS domain (unknown origin) at 100 uM by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProtein ENL(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50529556(CHEMBL4552313)
Affinity DataIC50: 260nMAssay Description:Inhibition of wild type human ENL YEATS expressed in Escherichia coli Rosetta cells by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed