BDBM50529465 CHEMBL4464632

SMILES COc1cc(NC(=O)C=C)ccc1Nc1nc(Nc2ccccc2C(N)=O)c2cc[nH]c2n1

InChI Key InChIKey=PYFNYNPQSUXBGV-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50529465   

TargetG protein-coupled receptor kinase 5(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50529465(CHEMBL4464632)
Affinity DataIC50: 220nMAssay Description:Inhibition of human GRK5 using tubulin as substrate measured after 4 hrs by [gamma-32P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetRhodopsin kinase GRK1(Bovine)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50529465(CHEMBL4464632)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of bovine GRK1 using tubulin as substrate measured after 4 hrs by [gamma-32P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Bovine)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50529465(CHEMBL4464632)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of bovine GRK2 using tubulin as substrate measured after 4 hrs by [gamma-32P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Bovine)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50529465(CHEMBL4464632)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of bovine GRK5 C474S mutant using tubulin as substrate measured after 4 hrs by [gamma-32P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50529465(CHEMBL4464632)
Affinity DataIC50: 5.90E+4nMAssay Description:Inhibition of human GRK5 using tubulin as substrate measured after 0 mins by [gamma-32P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50529465(CHEMBL4464632)
Affinity DataIC50: 1.13E+4nMAssay Description:Inhibition of human GRK5 using tubulin as substrate measured after 30 mins by [gamma-32P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50529465(CHEMBL4464632)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of human GRK5 using tubulin as substrate measured after 60 mins by [gamma-32P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50529465(CHEMBL4464632)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetG protein-coupled receptor kinase 5(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50529465(CHEMBL4464632)
Affinity DataIC50: 220nMAssay Description:Time dependent inhibition of GRK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetRhodopsin kinase GRK1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50529465(CHEMBL4464632)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GRK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed