BDBM50529458 CHEMBL4557065

SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc(CNC(=O)C#CC)cc2OC)nc2[nH]ccc12

InChI Key InChIKey=FCHSPYQBYVKMQM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50529458   

TargetG protein-coupled receptor kinase 5(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50529458(CHEMBL4557065)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of human GRK5 using tubulin as substrate measured after 100 mins by [gamma-32P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50529458(CHEMBL4557065)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human GRK5 using tubulin as substrate measured after 4 hrs by [gamma-32P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Bovine)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50529458(CHEMBL4557065)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of bovine GRK2 using tubulin as substrate measured after 4 hrs by [gamma-32P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Bovine)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50529458(CHEMBL4557065)
Affinity DataIC50: 700nMAssay Description:Inhibition of bovine GRK5 C474S mutant using tubulin as substrate measured after 4 hrs by [gamma-32P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50529458(CHEMBL4557065)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human GRK5 using tubulin as substrate measured after 0 mins by [gamma-32P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed