BDBM50529371 CHEMBL4522418::US10988487, Example 5

SMILES Nc1nonc1\C(N[C@@H]1Cc2ccccc12)=N\O

InChI Key InChIKey=OFIMOHDSAAYGBN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50529371   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50529371(CHEMBL4522418 | US10988487, Example 5)
Affinity DataIC50: 853nMAssay Description:Inhibition of IDO1 in human HeLa cells stimulated with IFNgamma using L-tryptophan as substrate incubated for 48 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50529371(CHEMBL4522418 | US10988487, Example 5)
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of recombinant His-tagged IDO1 (unknown origin) expressed in Escherichia coli preincubated for 30 mins followed by substrate tryptophan ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50529371(CHEMBL4522418 | US10988487, Example 5)
Affinity DataIC50: 75.8nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50529371(CHEMBL4522418 | US10988487, Example 5)
Affinity DataIC50: 1.24E+3nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent