BDBM50529038 CHEMBL4524407

SMILES OC(=O)c1ccc(-c2ccc(F)cc2)c(c1)S(F)(=O)=O

InChI Key InChIKey=HNGNJNXHCQAHBJ-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50529038   

TargetBcl-2-like protein 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50529038(CHEMBL4524407)
Affinity DataIC50: 9.92E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged Bcl-xl (1 to 209 residues) expressed in Escherichia coli using HyLite Fluor 647-labeled BIM pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50529038(CHEMBL4524407)
Affinity DataEC50: >3.15E+4nMAssay Description:Inhibition of Bcl-xl in human U266B1 cells assessed as caspase 3/7 activation for 6 hrs by Caspase 3/7-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50529038(CHEMBL4524407)
Affinity DataEC50: >3.15E+4nMAssay Description:Inhibition of Bcl-xl in human U266B1 cells assessed as caspase 3/7 activation in presence of 10 % serum for 6 hrs by Caspase 3/7-Glo luminescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed