BDBM50529035 CHEMBL4474764

SMILES CN(CC[C@H](CSc1ccccc1)Nc1ccc(cc1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c1ccc(-c2ccc(F)cc2)c(c1)S(F)(=O)=O)CC#C

InChI Key InChIKey=QJNDOGVVRBJVRJ-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50529035   

TargetBcl-2-like protein 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50529035(CHEMBL4474764)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged Bcl-xl (1 to 209 residues) expressed in Escherichia coli using HyLite Fluor 647-labeled BIM pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50529035(CHEMBL4474764)
Affinity DataIC50: 5.96E+3nMAssay Description:Inhibition of recombinant human C-terminal 6xHis-tagged Mcl-1 (E171 ti G327) expressed in Escherichia coli using biotin-labeled BIM peptide as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50529035(CHEMBL4474764)
Affinity DataEC50:  590nMAssay Description:Inhibition of Bcl-xl in human U266B1 cells assessed as caspase 3/7 activation for 6 hrs by Caspase 3/7-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50529035(CHEMBL4474764)
Affinity DataEC50: >3.15E+4nMAssay Description:Inhibition of Bcl-xl in human U266B1 cells assessed as caspase 3/7 activation in presence of 10 % serum for 6 hrs by Caspase 3/7-Glo luminescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50529035(CHEMBL4474764)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant human C-terminal 6xHis-tagged Bcl-2 (M1 to F212 residues) expressed in Escherichia coli using HyLite Fluor 647-labeled BIM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50529035(CHEMBL4474764)
Affinity DataIC50: 4.37E+3nMAssay Description:Inhibition of recombinant human N-terminal 6xHis-tagged Bcl-w (M1 to R171) expressed in Escherichia coli using HyLite Fluor 647-labeled Bim peptide a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed