BDBM50529030 CHEMBL4559485

SMILES C[C@@H](Oc1cc(cnc1N)-c1ccn(CCN(C)C)c(=O)c1)c1c(Cl)ccc(F)c1Cl

InChI Key InChIKey=NFAGZVGAXFNBPX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50529030   

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50529030(CHEMBL4559485)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ROS (1883 to 2347 residues) expressed in baculovirus expression system using IRS1 as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50529030(CHEMBL4559485)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK (1058 to 1620 residues) expressed in baculovirus expression system using Srctide as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50529030(CHEMBL4559485)
Affinity DataIC50: 45nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK L1196M mutant (1058 to 1620 residues) expressed in baculovirus expression system using Srct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50529030(CHEMBL4559485)
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK G1202R mutant (1058 to 1620 residues) expressed in baculovirus expression system using Srct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed