BDBM50528815 CHEMBL4468670

SMILES CCc1cnn2c(Nc3cccc(NC(=O)C=C)c3)cc(nc12)N1CCCC[C@H]1CCO

InChI Key InChIKey=CDCHESFKYUNJPV-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50528815   

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50528815(CHEMBL4468670)
Affinity DataIC50: 20nMAssay Description:Competitive irreversible inhibition of CDK9/cyclin T (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50528815(CHEMBL4468670)
Affinity DataIC50: 1.20E+3nMAssay Description:Competitive irreversible inhibition of CDK7/cyclinH/MAT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50528815(CHEMBL4468670)
Affinity DataIC50: 932nMAssay Description:Competitive irreversible inhibition of CDK2/cyclin E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 12(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50528815(CHEMBL4468670)
Affinity DataIC50: 74nMAssay Description:Inhibition of CDK12/Cyclin K (unknown origin) preincubated for 10 mins followed by substrate and ATP addition measured after 200 mins by ADP-Glo lumi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50528815(CHEMBL4468670)
Affinity DataIC50: 29nMAssay Description:Inhibition of CDK13/Cyclin K (unknown origin) preincubated for 10 mins followed by substrate and ATP addition measured after 200 mins by ADP-Glo lumi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed