BDBM50528604 CHEMBL4445335

SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc(NC(=O)C3(CC3)C(=O)Nc3ccc(C)cc3)cc2)ncc1F

InChI Key InChIKey=KJHIXFHBBTZCTR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50528604   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50528604(CHEMBL4445335)
Affinity DataIC50: 230nMAssay Description:Inhibition of recombinant human full length CDK2/CyclinA using as histone H1 substrate incubated for 40 mins in presence of [gamma-33P]-ATP by scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50528604(CHEMBL4445335)
Affinity DataIC50: 46nMAssay Description:Inhibition of recombinant full length human CDK4/Cyclin D3 using Rb-fragmen as substrate incubated for 40 mins by [gamma-33P]-ATP based radiometric a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50528604(CHEMBL4445335)
Affinity DataIC50: 46nMAssay Description:Inhibition of recombinant human VEGFR2 (790 to end residues) using myelin ba as substrate incubated for 40 mins by [gamma-33P]-ATP based radiometric ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50528604(CHEMBL4445335)
Affinity DataIC50: 247nMAssay Description:Inhibition of recombinant human full length CDK1/CyclinB using histone H1 as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed