BDBM50528218 CHEMBL4551664

SMILES COC(=O)c1cc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)ccc1S(=O)(=O)Nc1cc(Br)c(F)cc1C

InChI Key InChIKey=FKFQBYBODAKGOA-UHFFFAOYSA-N

Data  3 IC50  1 Kd  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50528218   

TargetNAD-dependent protein deacylase sirtuin-6(Human)
Shanghai Jiao-Tong University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50528218(CHEMBL4551664)
Affinity DataEC50:  1.03E+4nMAssay Description:Inhibition of SIRT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
Shanghai Jiao-Tong University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50528218(CHEMBL4551664)
Affinity DataEC50:  1.03E+4nMAssay Description:Allosteric activation of SIRT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
Shanghai Jiao-Tong University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50528218(CHEMBL4551664)
Affinity DataKd:  9.51E+3nMAssay Description:Binding affinity to N-terminal his-tagged human SIRT6 expressed in Escherichia coli M15 [pREP4] by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
Shanghai Jiao-Tong University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50528218(CHEMBL4551664)
Affinity DataEC50:  1.03E+4nMAssay Description:Activation of SIRT6 (unknown origin) deacetylase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
Shanghai Jiao-Tong University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50528218(CHEMBL4551664)
Affinity DataEC50:  1.03E+4nMAssay Description:Activation of SIRT6 (unknown origin) deacetylase activity using EALPKK-Myr-AMC substrate incubated for 2 hrs by FDL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50528218(CHEMBL4551664)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SIRT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50528218(CHEMBL4551664)
Affinity DataIC50: 1.05E+5nMAssay Description:Inhibition of SIRT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-7(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50528218(CHEMBL4551664)
Affinity DataIC50: 1.87E+5nMAssay Description:Inhibition of SIRT7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed