BDBM50528209 CHEMBL4526828

SMILES COc1cc(cc(OC)c1C(N)=O)-c1cncc(-c2ccc(cc2)N2C[C@H](C)N(C)[C@H](C)C2)c1C

InChI Key InChIKey=XCQPASNBVLQPAI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50528209   

TargetTGF-beta receptor type-1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50528209(CHEMBL4526828)
Affinity DataIC50: 283nMAssay Description:Inhibition of ALK5 (unknown origin) expressed in HEK293 cells transfected with CAGA-luciferase and Renilla luciferase reporter measured after 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50528209(CHEMBL4526828)
Affinity DataIC50: 3nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50528209(CHEMBL4526828)
Affinity DataIC50: 52nMAssay Description:Inhibition of C-terminal nanoluciferase-fused ALK2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs followed by NanoBRET NanoGlo Substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50528209(CHEMBL4526828)
Affinity DataIC50: 52nMAssay Description:Inhibition of human ALK5 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed