BDBM50528206 CHEMBL4457642

SMILES COc1cc(cc(c1)-c1cncc(c1C)-c1ccc(cc1)N1CCNCC1)C(N)=O

InChI Key InChIKey=LAJAERPQYKIOEV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50528206   

TargetTGF-beta receptor type-1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50528206(CHEMBL4457642)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of ALK5 (unknown origin) expressed in HEK293 cells transfected with CAGA-luciferase and Renilla luciferase reporter measured after 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50528206(CHEMBL4457642)
Affinity DataIC50: 588nMAssay Description:Inhibition of C-terminal nanoluciferase-fused ALK2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs followed by NanoBRET NanoGlo Substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50528206(CHEMBL4457642)
Affinity DataIC50: 102nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50528206(CHEMBL4457642)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human ALK5 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed