BDBM50528191 CHEMBL4575999

SMILES Cc1c(cncc1-c1ccc2C(=O)NCc2c1)-c1ccc(cc1)N1CCNCC1

InChI Key InChIKey=ZCLWKSOLVKDHKE-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50528191   

TargetActivin receptor type-1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50528191(CHEMBL4575999)
Affinity DataIC50: 2.34E+3nMAssay Description:Inhibition of C-terminal nanoluciferase-fused ALK2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs followed by NanoBRET NanoGlo Substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50528191(CHEMBL4575999)
Affinity DataIC50: 363nMAssay Description:Inhibition of ALK2 R258G mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50528191(CHEMBL4575999)
Affinity DataIC50: 171nMAssay Description:Inhibition of ALK2 G328V mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50528191(CHEMBL4575999)
Affinity DataIC50: 226nMAssay Description:Inhibition of human ALK2 R206H mutant using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50528191(CHEMBL4575999)
Affinity DataIC50: 652nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50528191(CHEMBL4575999)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human ALK5 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50528191(CHEMBL4575999)
Affinity DataIC50: 4.81E+3nMAssay Description:Inhibition of ALK5 (unknown origin) expressed in HEK293 cells transfected with CAGA-luciferase and Renilla luciferase reporter measured after 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed