BDBM50528188 CHEMBL4553210

SMILES COc1cc(ccc1C(N)=O)-c1cncc(c1C)-c1ccc(cc1)N1CCNCC1

InChI Key InChIKey=GFEAXKZXFORDDU-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50528188   

TargetActivin receptor type-1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50528188(CHEMBL4553210)
Affinity DataIC50: 55nMAssay Description:Inhibition of C-terminal nanoluciferase-fused ALK2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs followed by NanoBRET NanoGlo Substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50528188(CHEMBL4553210)
Affinity DataIC50: 576nMAssay Description:Inhibition of human ALK5 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50528188(CHEMBL4553210)
Affinity DataIC50: 17nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50528188(CHEMBL4553210)
Affinity DataIC50: 9nMAssay Description:Inhibition of ALK2 R258G mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50528188(CHEMBL4553210)
Affinity DataIC50: 5nMAssay Description:Inhibition of ALK2 G328V mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50528188(CHEMBL4553210)
Affinity DataIC50: 9nMAssay Description:Inhibition of human ALK2 R206H mutant using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50528188(CHEMBL4553210)
Affinity DataIC50: 704nMAssay Description:Inhibition of ALK5 (unknown origin) expressed in HEK293 cells transfected with CAGA-luciferase and Renilla luciferase reporter measured after 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed