BDBM50526890 CHEMBL4437566::US11912678, Compound 5

SMILES Clc1ccc2nc(NC(=O)c3ccc(cc3)N3CCOCC3)sc2c1

InChI Key InChIKey=BFNSMWQXBORNPV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50526890   

LigandPNGBDBM50526890(CHEMBL4437566 | US11912678, Compound 5)
Affinity DataIC50: 370nMAssay Description:Inhibition of wild type human GST-tagged LRRK2 (970 to 2527 residues) expressed in baculovirus expression system assessed as reduction in ADP formati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50526890(CHEMBL4437566 | US11912678, Compound 5)
Affinity DataIC50: 777nMAssay Description:The compounds were evaluated in LRRK2 and in the mutated form LRRK2 G2019S. This mutation is more frequent in the familial forms of Parkinson's D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
Go to US Patent