BDBM50526887 CHEMBL4445322::US11912678, Compound 4

SMILES Cc1ccc2nc(NC(=O)c3ccc(cc3)N3CCOCC3)sc2c1

InChI Key InChIKey=SZZZRXIIIMYPJS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50526887   

LigandPNGBDBM50526887(CHEMBL4445322 | US11912678, Compound 4)
Affinity DataIC50: 330nMAssay Description:Inhibition of human GST-tagged LRRK2 G2019S mutant (970 to 2527 residues) expressed in baculovirus expression system assessed as reduction in ADP for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50526887(CHEMBL4445322 | US11912678, Compound 4)
Affinity DataIC50: 480nMAssay Description:Inhibition of wild type human GST-tagged LRRK2 (970 to 2527 residues) expressed in baculovirus expression system assessed as reduction in ADP formati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50526887(CHEMBL4445322 | US11912678, Compound 4)
Affinity DataIC50: 523nMAssay Description:The compounds were evaluated in LRRK2 and in the mutated form LRRK2 G2019S. This mutation is more frequent in the familial forms of Parkinson's D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
Go to US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
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US Patent
LigandPNGBDBM50526887(CHEMBL4445322 | US11912678, Compound 4)
Affinity DataIC50: 332nMAssay Description:The compounds were evaluated in LRRK2 and in the mutated form LRRK2 G2019S. This mutation is more frequent in the familial forms of Parkinson's D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
Go to US Patent