BDBM50526882 CHEMBL4527232::US11912678, Compound 2

SMILES COc1ccc2nc(NC(=O)c3ccc(cc3)N3CCOCC3)sc2c1

InChI Key InChIKey=BDLBOSKLAVMJJO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50526882   

LigandPNGBDBM50526882(CHEMBL4527232 | US11912678, Compound 2)
Affinity DataIC50: 370nMAssay Description:Inhibition of wild type human GST-tagged LRRK2 (970 to 2527 residues) expressed in baculovirus expression system assessed as reduction in ADP formati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50526882(CHEMBL4527232 | US11912678, Compound 2)
Affinity DataIC50: 440nMAssay Description:Inhibition of human GST-tagged LRRK2 G2019S mutant (970 to 2527 residues) expressed in baculovirus expression system assessed as reduction in ADP for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50526882(CHEMBL4527232 | US11912678, Compound 2)
Affinity DataIC50: 368nMAssay Description:The compounds were evaluated in LRRK2 and in the mutated form LRRK2 G2019S. This mutation is more frequent in the familial forms of Parkinson's D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
Go to US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
Consejo Superior De Investigaciones Cientificas

US Patent
LigandPNGBDBM50526882(CHEMBL4527232 | US11912678, Compound 2)
Affinity DataIC50: 108nMAssay Description:The compounds were evaluated in LRRK2 and in the mutated form LRRK2 G2019S. This mutation is more frequent in the familial forms of Parkinson's D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
Go to US Patent