BDBM50526855 CHEMBL4580266::US20240199535, Example 4

SMILES OC(=O)c1sccc1C(=O)Nc1c(F)c(F)c(c(F)c1F)-c1cccc(OC(F)(F)F)c1

InChI Key InChIKey=VNDUHYWEWRRBFJ-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50526855   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Turin (Unito)

Curated by ChEMBL
LigandPNGBDBM50526855(CHEMBL4580266 | US20240199535, Example 4)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Turin (Unito)

Curated by ChEMBL
LigandPNGBDBM50526855(CHEMBL4580266 | US20240199535, Example 4)
Affinity DataKi:  3.70nMAssay Description:The in vitro inhibition of hDHODH was measured using an N-terminally truncated recombinant hDHODH enzyme as described in J. Med. Chem. 2006; 49:1239....More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent