BDBM50526727 CHEMBL4568508::US10807974, Example 100::US10995088, Example 100::US11608330, Example 100

SMILES CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1

InChI Key InChIKey=HQPYHGXLGJSYMM-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50526727   

TargetLysyl oxidase homolog 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526727(CHEMBL4568508 | US10807974, Example 100 | US109950...)
Affinity DataIC50: 587nMAssay Description:Inhibition of human C-terminal His10-tagged LOXL2 (Met1 to Gln774 residues) expressed in mouse NS0 cells using cadaverine hydrochloride as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetLysyl oxidase homolog 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526727(CHEMBL4568508 | US10807974, Example 100 | US109950...)
Affinity DataIC50: 69nMAssay Description:Inhibition of human C-terminal His10-tagged LOXL2 (Met1 to Gln774 residues) expressed in mouse NS0 cells using cadaverine hydrochloride as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526727(CHEMBL4568508 | US10807974, Example 100 | US109950...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MAOB expressed in baculovirus infected BTI insect cells using luminogenic MAO substrate measured after 1 hr by MAO-gl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetAmine oxidase [copper-containing] 3(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526727(CHEMBL4568508 | US10807974, Example 100 | US109950...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of recombinant human SSAO expressed in CHO cells using luminogenic MAO substrate measured after 1 hr by MAO-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526727(CHEMBL4568508 | US10807974, Example 100 | US109950...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells by Qpatch electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Pig)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526727(CHEMBL4568508 | US10807974, Example 100 | US109950...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of porcine kidney DAO measured after 1 hrs by ROS-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetLysyl oxidase homolog 3(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526727(CHEMBL4568508 | US10807974, Example 100 | US109950...)
Affinity DataIC50: 860nMAssay Description:Inhibition of recombinant C-terminal His-tagged human LOXL3 (1 to 753 residues) expressed in CHO cells using cadaverine hydrochloride as substrate pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526727(CHEMBL4568508 | US10807974, Example 100 | US109950...)
Affinity DataIC50: 5.93E+4nMAssay Description:Inhibition of recombinant human MAOA expressed in baculovirus infected BTI insect cells using luminogenic MAO substrate measured after 1 hr by MAO-gl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetLysyl oxidase homolog 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526727(CHEMBL4568508 | US10807974, Example 100 | US109950...)
Affinity DataIC50: 86nMAssay Description:Inhibition of human C-terminal His10-tagged LOXL2 (Met1 to Gln774 residues) expressed in mouse NS0 cells using cadaverine hydrochloride as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetLysyl oxidase homolog 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526727(CHEMBL4568508 | US10807974, Example 100 | US109950...)
Affinity DataIC50: 90nMAssay Description:LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

TargetDiamine oxidase [copper-containing](Human)
The Institute of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM50526727(CHEMBL4568508 | US10807974, Example 100 | US109950...)
Affinity DataIC50: 1.00E+5nMAssay Description:Promega ROS-Glo H2O2 Assay Kit, 50 ml. Cat No. G8821.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

TargetLysyl oxidase homolog 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526727(CHEMBL4568508 | US10807974, Example 100 | US109950...)
Affinity DataIC50: 90nMAssay Description:10. Incubate for 20 hrs at room temp on a plate shaker, protected from light.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
Go to US Patent

TargetD-amino-acid oxidase(Human)
The Institute of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM50526727(CHEMBL4568508 | US10807974, Example 100 | US109950...)
Affinity DataIC50: 1.00E+5nMAssay Description:ReagentsPromega ROS-Glo H2O2 Assay Kit, 50 ml. Cat No. G8821Inhibitors (Test Compounds):10 mM stock diluted to 10, 3, 1, 0.3, 0.1, 0.03, 0.01, 0.003,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
Go to US Patent

TargetLysyl oxidase homolog 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526727(CHEMBL4568508 | US10807974, Example 100 | US109950...)
Affinity DataIC50: 90nMAssay Description:MAO-Glo Assay Kit: Promega, Cat No. V1402MAO-A Enzyme: Promega, Cat No. V1452Clorgyline: Sigma, Cat No. M3778 (50 mg)Assay Plates:96 well white polys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetD-amino-acid oxidase(Human)
The Institute of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM50526727(CHEMBL4568508 | US10807974, Example 100 | US109950...)
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent