BDBM50525936 CHEMBL4577380

SMILES C[C@H](Nc1c(-c2nc3cnc(cc3[nH]2)N2CCOCC2)c(=O)[nH]c2cn(C)nc12)c1ncccn1

InChI Key InChIKey=QZYPCCCTXSBCNE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50525936   

TargetFibroblast growth factor receptor 3(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50525936(CHEMBL4577380)
Affinity DataIC50: 0.411nMAssay Description:Inhibition of human FGFR3 wild-type using FL-peptide substrate measured after 50 mins in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50525936(CHEMBL4577380)
Affinity DataIC50: 0.212nMAssay Description:Inhibition of human FGFR3 V555M mutant using FL-peptide substrate measured after 45 mins in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50525936(CHEMBL4577380)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of wild-type FGFR3 (unknown origin) expressed in mouse NIH/3T3 cells overexpressing wild type FGFR3-TACC3 assessed as inhibition of cell p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50525936(CHEMBL4577380)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of FGFR3 V555M mutant (unknown origin) expressed in mouse NIH/3T3 cells overexpressing FGFR3-V555M mutant TACC3 assessed as inhibition of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed