BDBM50525411 CHEMBL4443483
SMILES COc1cc2c(Nc3ccc(NC(=O)C(N4Cc5ccccc5C4=O)c4cc(F)ccc4F)cc3F)ncnc2cc1OCC1CCN(C)CC1
InChI Key InChIKey=RNUUQLALKWVVSI-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50525411
TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology
Curated by ChEMBL
East China University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 331nMAssay Description:Inhibition of EGFR 19D/T790M/C797S mutant (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 1 hr in presence of ATP by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology
Curated by ChEMBL
East China University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of recombinant human C-terminal His-tagged/N-terminal GST-tagged EGFR (668 to 1210 residues) T790M/L858R/C797S mutant expressed in baculov...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology
Curated by ChEMBL
East China University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology
Curated by ChEMBL
East China University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 331nMAssay Description:Inhibition of EGFR Del19/T790M/C797S triple mutant (unknown origin)More data for this Ligand-Target Pair