BDBM50525194 CHEMBL4471977

SMILES C[C@H]1SC(N)=N[C@@H]1CC(O)=O

InChI Key InChIKey=MQFCGOLHKFXDRZ-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50525194   

TargetSodium- and chloride-dependent GABA transporter 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50525194(CHEMBL4471977)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human GAT1 expressed in Flp-In CHO cells assessed as reduction in [3H]GABA uptake incubated for 3 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50525194(CHEMBL4471977)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human GAT2 expressed in Flp-In CHO cells assessed as reduction in [3H]GABA uptake incubated for 3 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50525194(CHEMBL4471977)
Affinity DataEC50:  1.70E+4nMAssay Description:Agonist activity at recombinant human GABA-A alpha5beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent betaine transporter(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50525194(CHEMBL4471977)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human BGT1 expressed in Flp-In CHO cells assessed as reduction in [3H]GABA uptake incubated for 3 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50525194(CHEMBL4471977)
Affinity DataEC50:  1.70E+4nMAssay Description:Agonist activity at recombinant human GABA-A alpha5beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50525194(CHEMBL4471977)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human GAT3 expressed in Flp-In CHO cells assessed as reduction in [3H]GABA uptake incubated for 3 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed