BDBM50524980 CHEMBL4437605

SMILES C[C@H](Nc1ccc2c(cn(-c3cc(C)n[nH]3)c2n1)C(=O)N1CCOCC1)c1ccc(F)cn1

InChI Key InChIKey=UYIANZRYPSGDFM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50524980   

TargetALK tyrosine kinase receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50524980(CHEMBL4437605)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human ALK kinase domain (1058 to 1620 residues) expressed in baculovirus expression system using biotin-poly-GT as substrate pre-incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50524980(CHEMBL4437605)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant human ALK expressed in HEK293 cells assessed as reduction in ALK autophosphorylation at Tyr1604 residue incubated for 60 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50524980(CHEMBL4437605)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of N-terminal GST-tagged human TrkA kinase domain (436 to 790 residues) expressed in baculovirus expression system using biotin-poly-GT as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50524980(CHEMBL4437605)
Affinity DataIC50: 2.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50524980(CHEMBL4437605)
Affinity DataIC50: 23nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed